REF MISC
N-Methyl-D-Aspartate Receptor Antibody IgG
Synonyms:
NMDA-IgG
NMDAR
Anti-NMDAR
Performing Lab:
Referral Laboratory
Container Type:
Plain red top or serum gel tube
Specimen Type:
Serum
Preferred Volume:
2 mL
Minimum Volume:
1 mL
Store and Transport:
Room Temperature
Stability:
Frozen - 14 days
Refrigerated - 14 days
Room temperature - 14 days
Unacceptable Condition:
CSF or plasma; contaminated, hemolyzed, or severely lipemic specimens
CPT Codes:
86255
Method:
Immunofluorescence (IFA)
Clinical Significance:
NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.
Anti-NMDAR1 encephalitis represents one of the most frequent causes of autoimmune encephalitis. This type of encephalitis may also be associated with post-COVID-19 related neurological symptoms.
Anti-NMDAR1 encephalitis represents one of the most frequent causes of autoimmune encephalitis. This type of encephalitis may also be associated with post-COVID-19 related neurological symptoms.