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Shanon Wolfe's varicose vein troubles were more than cosmetic. Although her legs didn’t hurt at the end of the day, more and more often they felt heavy and tired. It began interfering with her kickboxing.

Chris Williams was a healthy guy. The 36-year-old bodybuilder worked out regularly, played basketball, didn’t smoke, and watched his diet. Yet, in January 2012, Williams could barely drag himself out of bed. And walking a few steps across the room left him gasping for air.