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Ramon Grado doesn’t remember driving home and then sprawling on the living room floor on Jan. 13, 2013. Patty, his wife of 33 years, found him there an hour later, awake and complaining about his headache.

Chris Williams was a healthy guy. The 36-year-old bodybuilder worked out regularly, played basketball, didn’t smoke, and watched his diet. Yet, in January 2012, Williams could barely drag himself out of bed. And walking a few steps across the room left him gasping for air.