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For three years, Linda Braxdale endured throbbing pain in her lower back and down her left leg. The pain and frustration often left her feeling helpless and defeated—and reduced to tears.

Beth O’Connor hoped the sharp, searing pain that started in her chest and shot down to her belly was labor pangs and not her aortic artery coming apart.

David Hartzler was the epitome of health. A former collegiate swimmer, he had continued the sport into adulthood. Three times a week, the Lawrence, Kan., resident swam 3,000 meters with the Lawrence Masters Swim Club.