HLAB27
HLA-B27, Blood
EPIC Test Procedure Code: LAB3296
Synonyms:
HLA B 27 Disease Association
Performing Lab:
Referral Laboratory
Container Type:
Lavender top (EDTA) tube
Specimen Type:
Whole blood
Minimum Volume:
0.5 mL
Store and Transport:
Room temperature
Unacceptable Condition:
Samples that are hemolyzed, clotted or collected in tubes other than EDTA will be rejected.
CPT Codes:
81374 - HLA B 27 Disease Association (EAP 30020944)
Method:
Polymerase chain reaction (PCR) sequence-specific oligonucleotide probes (SSOP).
This test is a class I antigen level test.
This test is a class I antigen level test.
Reference Ranges:
Please refer to the performing lab report for applicable reference ranges
Clinical Significance:
Evaluate spondyloarthritis and other disorders associated with HLA-B27. HLA-B27 is strongly associated with ankylosing spondylitis (Marie-Strumpell disease). HLA-B27 shares homology with a Klebsiella protein and may imply a bacterial pathogenesis to ankylosing spondylitis. A patient with consistent clinical and radiographic findings who is B27-positive has a greater chance of having or developing ankylosing spondylitis than a negative patient. The antigen is not causative, however, and 10% of normal subjects are B27- positive. This test should not be considered a screening procedure for ankylosing spondylitis. The antigen is less strongly associated with Reiter syndrome and other arthritides than with ankylosing spondylitis. It has been linked with congenital deficiency of C4 and C2, and with adrenal hyperplasia.