REF MISC
DPD 5-Fluorouracil Toxicity
Synonyms:
Dihydropyrimidine Dehydrogenase Deficiency
DPYD
Performing Lab:
Referral Laboratory
Container Type:
Lavender top (EDTA)
Specimen Type:
Whole blood
Preferred Volume:
3 mL
Alternate Specimens:
Saliva Swab Collection Kit (T786) (Reference Lab does not keep these in stock. Advance arrangements would be required.)
Minimum Volume:
0.4 mL whole blood
Specimen Processing:
Send whole blood specimen in original tube. Do not aliquot.
Store and Transport:
Room temperature
Stability:
Room Temperature: 9 days
Refrigerated: 30 days
CPT Codes:
81232 (Z code: ZB6RO)
Method:
Real-Time Polymerase Chain Reaction (PCR) with Allelic Discrimination Analysis
Test Includes:
*2A, *7, *8, *10, *13, rs67376798, rs75017182, and rs115232898 alleles
Clinical Significance:
Identifying individuals with genetic variants in DPYD who are at increased risk of toxicity when prescribed 5-fluorouracil (5-FU) or capecitabine chemotherapy treatment.