REF MISC
Buprenorphine and Metabolite
Synonyms:
Buprenex
Free Buprenorphine
Subutex
Performing Lab:
Referral Laboratory
Container Type:
Plain red-top or green-top (heparin) tube (no gel)
Specimen Type:
Serum or plasma
NO Gel Tubes.
Preferred Volume:
3 mL
Minimum Volume:
0.5 mL
Collection Procedure:
Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible.
Store and Transport:
Room Temperature. For storage beyond three days, specimen should be refrigerated or frozen.
Stability:
Room Temperature: 14 days
Refrigerated: 14 days
Frozen: 14 days
Unacceptable Condition:
Gel-barrier tube
CPT Codes:
80299
Method:
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Clinical Significance:
Buprenorphine is used in the management of moderate to severe chronic pain.
Half-life elimination: IV: 2.2 to 3 hours, Sublingual tablet: approximately 37 hours, Transdermal patch: approximately 26 hours
Time to peak plasma: Sublingual: 30 minutes to 1 hour
Half-life elimination: IV: 2.2 to 3 hours, Sublingual tablet: approximately 37 hours, Transdermal patch: approximately 26 hours
Time to peak plasma: Sublingual: 30 minutes to 1 hour